Topol on Notable Cancer, Drug, and Wearable Technology News: "Also in genomics, I'd like to mention a major report on pharmacogenomics and the response to lithium for bipolar disorder. [4] A sequence variant fully predicted whether there would be a clinical response in a cohort of Han Chinese individuals, with replication and an odds ratio of 120! Very high odds ratios are not so unusual with drug response or major side effects, and I have included a table below that I put together to show the top odds ratios reported so far. Sadly, we are sitting in prescription medicine darkness, whence there are over 6000 medications and there are genomic data for less than 2% of them. Much more needs to be done for commonly prescribed meds and for those in clinical investigation."
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